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Image Search Results
Journal: Molecular Therapy. Nucleic Acids
Article Title: RNA activation of CEBPA improves leukemia treatment
doi: 10.1016/j.omtn.2025.102611
Figure Lengend Snippet: NOV340 liposomes deliver RNA into AML cells in vitro via macropinocytosis (A) Graphic of Cy3-MTL-CEBPA and controls. (B) Delivery of fluorescently tagged CEBPA-51 saRNA in myeloid leukemia and lymphoid leukemia cell lines. Two-way ANOVA with Holm-Sidak multiple comparison test; n = 3. Data represented as mean (SD). (C) Schematic of endocytosis inhibitors used for in vitro uptake inhibition assay. (D) Representative histograms of Cy3 fluorescence in AML cell lines after treatment with clathrin-mediated endocytosis inhibitor, Pitstop 2, or macropinocytosis inhibitors, EIPA or imipramine. (E) Changes in uptake of Cy3-MTL-CEBPA following treatment with endocytosis inhibitors in THP-1, MOLM-14, and KG1a cells. Two-way ANOVA with Holm-Sidak multiple comparison test; n = 3. Data represented as mean (SD).
Article Snippet:
Techniques: Liposomes, In Vitro, Comparison, Inhibition, Fluorescence
Journal: Cancers
Article Title: BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia
doi: 10.3390/cancers13030581
Figure Lengend Snippet: Genetic variants in acute myeloid leukemia (AML) cell lines.
Article Snippet:
Techniques:
Journal: Cancers
Article Title: BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia
doi: 10.3390/cancers13030581
Figure Lengend Snippet: Combination index values AML cell lines (Chou and Talalay).
Article Snippet:
Techniques: